abstract：:Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...

journal_title：BioMed research international

authors： Zhu M,Yang M,Yang Q,Liu W,Geng H,Pan L,Wang L,Ge R,Ji L,Cui S,Li Z

更新日期：2020-01-23 00:00:00

abstract：:Myofascial pain syndrome is characterized by pain and a limited range of joint motion caused by muscle contracture related to motor-end-plate dysfunction and the presence of myofascial trigger points (MTrPs). It is the most frequent cause of musculoskeletal pain, with a worldwide prevalence varying between 13.7% and 4...

journal_title：BioMed research international

authors： Wada JT,Akamatsu F,Hojaij F,Itezerote A,Scarpa JC,Andrade M,Jacomo A

更新日期：2020-01-22 00:00:00

abstract：:Pathological studies have shown an association between psoriasis and renal injury (RI), but the mechanism between RI and psoriasis was still unclear. This paper was designed to investigate the relationship and mechanism between psoriasis-like inflammation and renal injury in BALB/C mice. Mice were topically smeared im...

journal_title：BioMed research international

authors： Ren F,Zhang M,Zhang C,Sang H

更新日期：2020-01-21 00:00:00

abstract：Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...

journal_title：BioMed research international

authors： Irie T,Takahashi N,Kamoshida T,Kashimura J,Ariga H

更新日期：2020-01-19 00:00:00

abstract：:Panax ginseng Meyer, a valuable medicinal plant, is severely threatened by rusty root, a condition that greatly affects its yield and quality. Studies investigating the relationship between soil microbial community composition and rusty roots are vital for the production of high-quality ginseng. Here, high-throughput ...

journal_title：BioMed research international

authors： Wei X,Wang X,Cao P,Gao Z,Chen AJ,Han J

更新日期：2020-01-15 00:00:00

abstract：:A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimula...

journal_title：BioMed research international

authors： Baktybayeva L,Yu V,Zazybin A,Zolotareva D,Dauletbakov A

更新日期：2020-01-13 00:00:00

abstract：Objective:Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the...

journal_title：BioMed research international

authors： Gong X,Huang MY

更新日期：2020-01-11 00:00:00

abstract：:Abnormal expression of neuroepithelial cell transforming gene 1 (NET1) has been authenticated in many human cancers, including lung cancer. We have previously reported that NET1 functioned as an oncogene and promoted human non-small-cell lung cancer (NSCLC) growth and migration. However, the correlation between NET1 a...

journal_title：BioMed research international

authors： Ding S,Huang H,Xu Y,Shen L,Zhong C,Zheng S

更新日期：2020-01-11 00:00:00

abstract：Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...

journal_title：BioMed research international

authors： Chen F,Ju H,Huang A,Yi Y,Cao Y,Xie W,Wang X,Fu G

更新日期：2020-01-10 00:00:00

abstract：:This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...

journal_title：BioMed research international

authors： Chen R,Chen Q,Wu X,Che Y,Wang C,Wang L,Yan S,Zhou L

更新日期：2020-01-10 00:00:00

abstract：:Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...

journal_title：BioMed research international

authors： Nugraha RY,Faratisha IF,Mardhiyyah K,Ariel DG,Putri FF,Nafisatuzzamrudah,Winarsih S,Sardjono TW,Fitri LE

更新日期：2020-01-09 00:00:00

abstract：:Within-litter birth weight variation in multiparous animals has become a big issue due to high incidence of low birth weight neonates, which gives rise to high preweaning mortality and morbidity. Foetus with various birth weights is the outcome of diverse embryos competence which is affected by oocyte quality. Glucosa...

journal_title：BioMed research international

authors： Feng C,Yuan T,Wang S,Liu T,Tao S,Han D,Wang J

更新日期：2020-01-08 00:00:00

abstract：:Cervical cancer is one of the malignant tumors that seriously threaten women's health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanis...

journal_title：BioMed research international

authors： Hu T,Zhang Q,Gao L

更新日期：2020-01-03 00:00:00

abstract：:Hypertrophic Scars (HTSs) are a complex fibroproliferative disorder, and their exact mechanism is still not fully understood. In this study, we first found that cystic fibrosis transmembrane conductance regulator (CFTR) expression was downregulated in human hypertrophic scars at the RNA and protein levels by microarra...

journal_title：BioMed research international

authors： Zhou Y,Zhao Y,Du H,Suo Y,Chen H,Li H,Liang X,Li Q,Huang X

更新日期：2020-01-02 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a very aggressive malignant type of tumor that currently lacks effective targeted therapies. In hematological malignancies, chimeric antigen receptor T (CAR-T) cells have shown very significant antitumor ability; however, in solid tumors, the efficacy is poor. In order to apply ...

journal_title：BioMed research international

authors： Zhao Z,Li Y,Liu W,Li X

更新日期：2020-01-02 00:00:00

abstract：Objective:To assess the application value of perfusion-weighted imaging (PWI) in early diagnosis, quantitation, and hepatic fibrosis staging by analyzing the related parameters in hepatic fibrosis. Methods:A total of 60 rats were randomly divided into the hepatic fibrosis and control groups, and carbon tetrachloride (...

journal_title：BioMed research international

authors： Fan G,Ya Y,Ni X,Hou J,Yu R

更新日期：2019-12-28 00:00:00

abstract：:The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...

journal_title：BioMed research international

authors： Abdallah BM,Ali EM,Elsawy H,Badr GM,Abdel-Moneim AM,Alzahrani AM

更新日期：2019-12-28 00:00:00

abstract：:Tripartite Motif Containing 11 (TRIM11), an E3 ubiquitin ligase, is identified as a carcinogen causing certain human cancers. However, the specific role of TRIM11 is still uncovered in human osteosarcoma (OS) cells. To explore the role of TRIM11 in OS cells, TRIM11 was induced by silencing and overexpression in OS cel...

journal_title：BioMed research international

authors： Wang Z,Xu X,Tang W,Zhu Y,Hu J,Zhang X

更新日期：2019-12-25 00:00:00

abstract：Introduction:The use of blue light-emitting devices (smartphones, tablets, and laptops) at bedtime has negative effects on sleep due to light stimulation and/or problematic excessive use. We aimed to evaluate, among young medical students, if the perception of sleep disturbances due to bedtime use of these devices is c...

journal_title：BioMed research international

authors： Jniene A,Errguig L,El Hangouche AJ,Rkain H,Aboudrar S,El Ftouh M,Dakka T

更新日期：2019-12-24 00:00:00

abstract：Background:The Biodex Biosway® Balance System and SWAY Balance® Mobile smartphone application (SBMA) are portable instruments that assess balance function with force plate and accelerometer technology, respectively. The validity of these indirect clinical measures of postural sway merits investigation. Purpose:The pur...

journal_title：BioMed research international

authors： Dewan BM,Roger James C,Kumar NA,Sawyer SF

更新日期：2019-12-21 00:00:00

abstract：Background:Many studies, comparing the health associated risks of electronic cigarettes with conventional cigarettes focus mainly on the common chemical compounds found between them. Aim:Review chemical compounds found exclusively in electronic cigarettes and describe their toxic effects, focusing on electronic-cigare...

journal_title：BioMed research international

authors： Armendáriz-Castillo I,Guerrero S,Vera-Guapi A,Cevallos-Vilatuña T,García-Cárdenas JM,Guevara-Ramírez P,López-Cortés A,Pérez-Villa A,Yumiceba V,Zambrano AK,Leone PE,Paz-Y-Miño C

更新日期：2019-12-19 00:00:00

abstract：:Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...

journal_title：BioMed research international

authors： Al Mehdi K,Fouad B,Zouhair E,Boutaina B,Yassine N,Chaimaa AEC,Najat S,Hassan R,Rachida R,Abdelhamid B,Halima N

更新日期：2019-12-17 00:00:00

abstract：Background:Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in the hypoxic microenvironment of tumor tissue. Adenosine signaling via A2aR can inhibit the antitumor immune response of CD8+ T cells. CD39 and CD73 high-expressing Tregs play a cr...

journal_title：BioMed research international

authors： Shi L,Feng M,Du S,Wei X,Song H,Yixin X,Song J,Wenxian G

更新日期：2019-12-14 00:00:00

abstract：Objective:The use of a biofabrication nerve scaffold, which mimics the nerve microstructure, as an alternative for autologous nerve transplantation is a promising strategy for treating peripheral nerve defects. This study aimed to design a customized biofabrication scaffold model with the characteristics of human perip...

journal_title：BioMed research international

authors： Yao Z,Yan LW,Qiu S,He FL,Gu FB,Liu XL,Qi J,Zhu QT

更新日期：2019-12-14 00:00:00

abstract：:This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...

journal_title：BioMed research international

authors： Zhang ZY,Li YC,Geng CY,Wang HJ,Chen WM

更新日期：2019-12-14 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/2109865.]. ...

journal_title：BioMed research international

authors： You J,Chen W,Chen J,Zheng Q,Dong J,Zhu Y

更新日期：2019-12-13 00:00:00

abstract：:Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...

journal_title：BioMed research international

authors： de Souza Fernandez T,Fonseca Alvarenga T,Almeida Antônio de Kós E,Lamim Lovatel V,Tavares RC,da Costa ES,de Souza Fernandez C,Abdelhay E

更新日期：2019-12-10 00:00:00

abstract：:The treatment of traumatic low-degree vertebral compression fracture remains in a wide range between functional treatment, bracing, vertebroplasty, kyphoplasty, and even surgical fixation. The objective was to assess the innovation of instrumented kyphoplasty and to report the early and mid-term functional and radiolo...

journal_title：BioMed research international

authors： Descamps J,Lamerain M,Chenguel Z,Jubert P,Rousseau MA

更新日期：2019-12-10 00:00:00

abstract：:Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...

journal_title：BioMed research international

authors： Chen Y,Suo J,Du M,Chen L,Liu Y,Wang L,Liang Z

更新日期：2019-12-09 00:00:00

abstract：Objective:The aim of this study is to explore the potential pathogenesis of juvenile dermatomyositis by bioinformatics analysis of gene chips, which would screen the hub genes, identify potential biomarkers, and reveal the development mechanism of juvenile dermatomyositis. Material and Methods:We retrieved juvenile de...

journal_title：BioMed research international

authors： Qiu CC,Su QS,Zhu SY,Liu RC

更新日期：2019-12-07 00:00:00

abstract：:This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells a...

journal_title：BioMed research international

authors： Revin VV,Gromova NV,Revina ES,Prosnikova KV,Revina NV,Bochkareva SS,Stepushkina OG,Grunyushkin IP,Tairova MR,Incina VI

更新日期：2019-12-07 00:00:00

abstract：:Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...

journal_title：BioMed research international

authors： Christou N,Meyer J,Popeskou S,David V,Toso C,Buchs N,Liot E,Robert J,Ris F,Mathonnet M

更新日期：2019-12-04 00:00:00

abstract：:Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...

journal_title：BioMed research international

authors： Ekanayake CP,Thammitiyagodage MG,Padumadasa S,Seneviratne B,Padumadasa C,Abeysekera AM

更新日期：2019-12-03 00:00:00

abstract：Purpose:Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the ...

journal_title：BioMed research international

authors： Xu J,Xu G,Zhang T,Chen T,Zhao W,Wang G

更新日期：2019-11-30 00:00:00

abstract：Background:Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ALCF) is a complicated syndrome with extremely high short-term mortality. The artificial liver support system (ALSS) may improve the liver function for patients with HBV-ACLF, but the data on its short-term outcomes are insufficient in China. ...

journal_title：BioMed research international

authors： Xiao LL,Xu XW,Huang KZ,Zhao YL,Zhang LJ,Li LJ

更新日期：2019-11-29 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...

journal_title：BioMed research international

authors： Uzrail AH,Assaf AM,Abdalla SS

更新日期：2019-11-29 00:00:00

abstract：:Metastasis is the leading cause of lung cancer-associated death. Downregulated expression of E-cadherin followed by epithelial-mesenchymal transition (EMT) is critical for metastasis initiation in lung cancer. BTBD7 plays essential roles in lung cancer metastasis, but the mechanisms remain unknown. This study aimed to...

journal_title：BioMed research international

authors： Shu J,Wang L,Han F,Chen Y,Wang S,Luo F

更新日期：2019-11-27 00:00:00

abstract：Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...

journal_title：BioMed research international

authors： Wu X,Sun W,Tan M

更新日期：2019-11-26 00:00:00

abstract：Objective:To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol. Methods:A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases ...

journal_title：BioMed research international

authors： Li X,Yang K,Li H,Huo R

更新日期：2019-11-25 00:00:00

abstract：:Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

journal_title：BioMed research international

authors： Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

更新日期：2019-11-20 00:00:00